Brad Name | Proze -D |
Composition | Pantaprazole 40 MG + Domperidone 10 MG Tablets |
Pantoprazole is a drug acting as a proton pump inhibitor in the parietal cells of the stomach, which are in charge of acid secretion. It blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme, the production of acid is decreased, and this allows the stomach and esophagus to heal. It is used in the treatment and prevention of acid peptic disease. Once ingested pantoprazole is activated in the gastric medium, and its absolute bioavailability is 77%. Pantoprazole diminishes the daily production of acid by 80- 95 %.
Domperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect. It acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. It is used in migraine to relieve nausea and vomiting.
1 tablet once daily.
Headache, dizziness, nausea, vomiting, gas, joint pain, blistering or peeling skin, rash, hives, itching, swelling of the eyes, face, lips, mouth, throat, or tongue, difficulty breathing or swallowing, hoarseness, irregular, fast, or pounding heartbeat, excessive tiredness, dizziness, lightheadedness, muscle spasms, uncontrollable shaking of a part of the body, seizures, severe diarrhea with watery stools, stomach pain, fever
Pantoprazole may reduce the absorption of ketoconazole, itraconazole, posaconazole, erlotinib when used concomitantly.
Co-administration of pantoprazole with atazanavir is not recommended.
Concurrent administration with MAO inhibitors is not recommended